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WelChol(R) (colesevelam HCl) and Lipitor(R) (atorvastatin calcium), taken in combination, can lower LDL cholesterol levels by 48% in patients with moderately high cholesterol — a reduction statistically superior to either therapy alone — according to a new study published in the October 2001 issue of Atherosclerosis. The study demonstrated that patients receiving this combination (3.8 g WelChol plus 10 mg Lipitor) experienced additive reductions in LDL cholesterol that were not significantly different from the maximum recommended dose of Lipitor alone (80 mg).[1]
This is welcome information for the new National Cholesterol Education Program (NCEP) guidelines. Issued this past May, the guidelines specify that patients at high risk for coronary heart disease must be treated more aggressively. They go on to note that combination therapy is a safe and effective way of lowering LDL cholesterol and reaching goal. “The results of WelChol/Lipitor coadministration suggest that this combination may be beneficial in lowering LDL cholesterol to NCEP recommended target levels for patients with or at risk of developing CHD,” said Donald Hunninghake, MD, principal study investigator and professor of medicine and pharmacology at the University of Minnesota.
This is the third such combination study with WelChol plus a leading statin demonstrating the two work better than either alone. The prior studies were conducted with simvastatin (Zocor(R)) and lovastatin (Mevacor(R)).
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